Author

K. Yaguchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Research Focus:development & morphogenesis· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

R. Uehara· 4 shared K. Yoshizawa· 3 shared T. Yamamoto· 2 shared A. Matsura· 1 shared A. Shibanuma· 1 shared B. D. Ryder· 1 shared B. F. Gomes· 1 shared E. Kawamoto· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersCell Biology

R. Uehara

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Author profile →

5 papers

Recent·Most cited

Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength

M. U. Rios, M. A. Bagnucka, B. D. Ryder, B. F. Gomes, N. Familiari, K. Yaguchi, M. Amato, Łukasz A. Joachimiak, J. B. Woodruff

The paper identifies coiled-coil interactions in SPD-5 that enable centrosome assembly and strength by resisting microtubule-mediated forces.

bioRxiv · May 15, 2023 · PreprintCell Biology

Tetraploidy-linked sensitization to CENP-E inhibition in human cells

K. Yoshizawa, A. Matsura, M. Shimada, S. Ishida-Ishihara, T. Yamamoto, K. Yaguchi, E. Kawamoto, T. Kuroda, K. Matsuo, N. Tamaoki, R. Sakai, M. Mishra, R. Uehara

This study shows that tetraploid cells are more sensitive to CENP-E inhibitors than diploid cells, leading to selective growth suppression through mitotic delay and cohesion fatigue.

Molecular Oncology · Feb 11, 2023Peer-reviewedCell Biology

Mevalonate pathway-mediated ER homeostasis is required for haploid stability in human somatic cells

K. Yaguchi, K. Sato, K. Yoshizawa, G. Banhegyi, E. Margittai, R. Uehara

This study shows that the mevalonate pathway regulates ER homeostasis, which is essential for maintaining haploid stability in human somatic cells.

bioRxiv · Nov 5, 2020Cell Biology

Uncoupling of DNA replication and centrosome duplication cycles is a primary cause of haploid instability in mammalian somatic cells

K. Yoshizawa, K. Yaguchi, R. Uehara

This study shows that uncoupling DNA replication and centrosome duplication causes haploid instability in mammalian cells and demonstrates a method to restore coupling and improve stability.

bioRxiv · May 30, 2020Cell Biology

Uncoordinated centrosome duplication cycle underlies the instability of non-diploid states in mammalian somatic cells

K. Yaguchi, R. Matsui, T. Yamamoto, Y. Tsukada, A. Shibanuma, K. Kamimura, T. Koda, R. Uehara

The paper shows that centrosome duplication cycle incompatibility with DNA replication causes instability in non-diploid mammalian somatic cells.

bioRxiv · Sep 27, 2017Cell Biology