B. D. Ryder

De novo designed Hsp70 activator dissolves intracellular condensates

The paper designs Hsp70 activators that dissolve intracellular condensates by modulating Hsp70 ATPase activity and promoting protein refolding.

A central helical hairpin in SPD-5 enables centrosome strength and assembly

The paper identifies a helical hairpin in SPD-5 critical for centrosome assembly and strength, showing mutations disrupt PCM formation and resilience to microtubule forces.

Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength

The paper identifies coiled-coil interactions in SPD-5 that enable centrosome assembly and strength by resisting microtubule-mediated forces.

DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity

This paper identifies an aromatic-rich motif in DNAJB8 that mediates oligomerization and shows that disrupting this motif affects oligomerization but not substrate activity.

Biophysical properties of a tau seed

This study characterizes the biophysical properties of tau seeds, showing they are monomeric and can nucleate tau aggregation in vitro and in cells.

DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation

This study identifies DnaJC7's interaction with tau's beta-turn element to inhibit amyloid formation, suggesting a mechanism for tau aggregation regulation.

Auto-regulatory J-domain interactions control Hsp70 recruitment to the DnaJB8 chaperone

This study identifies an auto-regulatory J-domain interaction in DnaJB8 that controls Hsp70 recruitment by sequestering the J-domain surface.

Tau local structure shields amyloid motif and controls aggregation propensity

The paper investigates how local structure in tau protein modulates aggregation propensity and how mutations disrupt this structure to trigger amyloid formation.