KSHV vIL-6 Enhances Inflammatory Responses by Epigenetic Reprogramming
T. Inagaki, K.-H. Wang, A. Kumar, C. Izumiya, H. Miura, S. Komaki, R. R. Davis, C. Tepper, H. Katano, M. Shimoda, Y. Izumiya
This study shows that prolonged KSHV-encoded vIL-6 exposure reprograms chromatin to enhance inflammatory cytokine production through BRD4-mediated mechanisms.
bioRxiv · Jun 25, 2023Microbiology