Kai Yu

Species-Specific Roles of RIPK1 and TRADD in TNF-Induced Cell Death Reveal a Translational Gap Between Mouse Models and Human Biology

This study identifies species-specific differences in TNF-induced cell death mechanisms between human and mouse cells, highlighting discrepancies in RIPK1 and TRADD function that affect drug efficacy.

mTORC1 Directs TNF-Induced Life-or-Death Decisions via Complex I Destabilization

This paper shows mTORC1 regulates TNF-induced cell death by destabilizing complex I and promoting complex II formation, with implications for disease therapies.

Integration of spatial single-cell proteomics and spatial metabolomics reveals tumor microenvironment predictive of immunotherapy response in mucosal melanoma

Single-cell lung eQTL dataset of Asian never-smokers highlights the roles of alveolar cells in lung cancer etiology

The paper constructs a single-cell eQTL dataset from Asian never-smokers, identifying alveolar cell-specific genes linked to lung cancer susceptibility.

Identifying High-Dimensional Genomic Factors Modulating Biological Networks Across Multi-Omics Data

GFBioNet identifies genomic factors modulating trait-trait relationships in multi-omics data, revealing host genetics, microbial taxa, and mutations affecting biological networks.

A Powerful Procedure for Pathway-based Meta-Analysis Using Summary Statistics Identifies 43 Pathways Associated with Type II Diabetes in European Populations

This paper introduces sARTP, a pathway-based meta-analysis method using summary statistics, identifying 43 T2D-associated pathways in European populations and 7 trans-ethnic pathways in Asian populations.

Winners curse correction and variable thresholding improve performance of polygenic risk modeling based on summary-level data from genome-wide association studies

This paper improves polygenic risk scores by applying winners curse correction and variable thresholds to GWAS summary data, enhancing prediction accuracy for some diseases.