ImmunologyNature ImmunologyPeer-reviewed
Stepwise neofunctionalization of the NF-κB family member c-Rel during vertebrate evolution
Allison E. Daly, Abraham B. Chang, Prabhat Kumar Purbey…·Stephen T. Smale
The paper shows c-Rel, an NF-κB family member, evolved unique DNA-binding properties in mammals, enhancing its ability to regulate Il12b and support immune complexity.
9 citations