Stephen T. Smale

This study shows that loss of Smyd5 in cardiomyocytes causes inflammation and heart failure in mice by reducing H4K20me3 and increasing Il-6 expression.

The paper shows c-Rel, an NF-κB family member, evolved unique DNA-binding properties in mammals, enhancing its ability to regulate Il12b and support immune complexity.

This study compares ChIP-seq and CUT&Tag for NFκB transcription factor genomic interactions, showing how experimental conditions affect detected interactions and their functional relevance.

The paper identifies a p50-IκBζ pathway that selectively activates immunoregulatory genes in TLR4-stimulated macrophages, contributing to differential responses compared to TNFR stimulation.

The paper shows that alternative splicing of DPF2, regulated by PTBP1, affects chromatin organization and transcriptional regulation during stem cell maintenance and neuronal differentiation.

The paper develops a framework to analyze nucleosome remodeling in response to stimuli and finds that remodeling preferentially affects poorly positioned nucleosomes at enhancers.

This study compares OSKM reprogramming factor binding in human and mouse fibroblasts, finding conserved mechanisms and species-specific differences in target sites and regulatory networks.