BiophysicsbioRxivPreprint
ML277 specifically enhances pore opening of KCNQ1 with VSD at the activated state by modulating VSD-pore coupling
Panpan Hou, Jingyi Shi, Kelli McFarland White…·Jianmin Cui
This study shows ML277 enhances the AO state of KCNQ1 channels by improving VSD-pore coupling, offering a potential therapy for long QT syndrome.
DOI 10.1101/624478