Panpan Hou

This study determines the structure of KCNQ1+KCNE1 in closed and open states, revealing structural transitions and dual PIP2 binding that regulate channel gating and IKs function.

This paper identifies the fully activated open state of KCNQ1 as critical for β-adrenergic stimulation of IKs channels, showing that modulators enhancing this state can restore function in LQT1 mutants.

This study shows ML277 enhances the AO state of KCNQ1 channels by improving VSD-pore coupling, offering a potential therapy for long QT syndrome.