Molecular BiologyFrontiers in Aging NeurosciencePeer-reviewed
Tau-induced elevation in promoter-proximal RNA polymerase II pausing is linked to decreased expression of long neuronal genes in a Drosophila tauopathy model.
Kendall Cottingham, Nima Goodarzi, David Fries…·Hana Hall
The paper investigates how pathological tau affects gene expression in a Drosophila tauopathy model, finding increased RNA polymerase II pausing linked to reduced expression of long neuronal genes.
DOI 10.3389/fnagi.2026.1851916