Kion T. Winston

This paper develops a head-fixed ethanol self-administration model in mice, demonstrating reliable ethanol-seeking behavior and relapse-like reinstatement of lever pressing.

This study uses two-photon calcium imaging to analyze corticostriatal neuron activity in mice during heroin self-administration and relapse, identifying distinct neuronal ensembles and their role in drug-seeking behaviors.

The paper identifies specialized neuronal ensembles in the dmPFC that encode reward-related information during conditioning, showing differential emergence and stabilization across learning.

This paper describes a new experimental assay allowing mice to self-administer drugs while head-restrained, enabling simultaneous multiphoton imaging of neural activity during drug use and relapse.