Leaky scanning translates a conserved ORF in the 3'UTR of RPL36A and regulates the expression of ribosomal protein L36a.
Debraj Manna, Japita Ghosh, Solanki Dhruvi Chetanbhai…·Sandeep M. Eswarappa
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Indian Institute of Science Bangalore
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4 papers
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Debraj Manna, Japita Ghosh, Solanki Dhruvi Chetanbhai…·Sandeep M. Eswarappa
Kirtana Vasu, Swati Ghosh, Sarthak Sahoo…·Sandeep M. Eswarappa
The paper identifies a conserved four-codon dORF in the 3'UTR of MAP3K10 regulated by an RNA G-quadruplex, which modulates MAP3K10 expression.
Saubhik Som, Gopalapura J. Vishalakshi, Lekha E. Manjunath…·Sandeep M. Eswarappa
The paper introduces an in vivo assay to study gene expression regulation without animal sacrifice, demonstrating its use for promoter, microRNA, stop codon readthrough, and rare codon effects.
Lekha E. Manjunath, Anumeha Singh, Sangeetha Devi Kumar…·Sandeep M. Eswarappa
This paper describes a CRISPR-dCas13 system to induce stop codon readthrough in specific transcripts, showing enhanced readthrough in AGO1, VEGFA, and HBB mRNAs.