BiochemistrybioRxiv
Atomic structure of Hsp90:Cdc37:Cdk4 reveals Hsp90 regulates kinase via dramatic unfolding
Kliment A Verba, Ray YR Wang, Akihiko Arakawa…·David A Agard
The paper reports the first structure of a Hsp90:Cdc37:Cdk4 complex, revealing Hsp90 stabilizes kinases by trapping them in an unfolded state.