Necroptotic Signalling Diverts Keratinocyte Fate to Promote Differentiation and Slow Wound Healing
Holly Anderton, H Yingxue, Natasha Silke, Anisha Lynch‐Godrei, Lok He Gu, Stacey Brown, Kosuke Shimada, Esther Bandala‐Sanchez, Wayne Cawthorne, Shene Chiou, Anne Hempel, André L. Samson, James M. Murphy, John Silke
This study shows that necroptosis in keratinocytes promotes differentiation and slows wound healing by preserving barrier integrity, suggesting it can be modulated to enhance tissue repair.
bioRxiv · Jul 15, 2026 · PreprintCell Biology