Kshitiz

Placental invasion mismatch underlines pregnancy disorders and cancers

The paper identifies conserved regulatory programs in placental invasion across mammals and links their dysregulation to pregnancy disorders and cancers.

Lightsheet microscopy integrates single-cell optical visco-elastography and fluorescence cytometry of 3D live tissues

The paper introduces a method combining lightsheet microscopy with optical visco-elastography to analyze single-cell mechanics and fluorescence in 3D live tissues, revealing new insights into cellular interactions.

Stable and Oscillatory Hypoxia Differentially Regulate Invasibility of Breast Cancer Associated Fibroblasts

This study shows that stable and oscillatory hypoxia differentially regulate the invasiveness of breast cancer-associated fibroblasts through distinct molecular and mechanical mechanisms.

Oscillatory Hypoxia Induced Unfolded Protein Folding Response Gene Expression Predicts Low Survival in Human Breast Cancer Patients

The paper shows oscillatory hypoxia induces a unique gene expression signature in breast cancer linked to poor survival.

Experimental and Phylogenetic Evidence for Correlated Gene Expression Evolution between Dermal and Endometrial Fibroblasts: implications for the evolution of cancer malignancy

The paper investigates correlated gene expression evolution between dermal and endometrial fibroblasts across species and in an experimental model, finding significant correlations that support evolutionary links to cancer malignancy.

Cis-Regulatory Differences Explaining Evolved Levels of Endometrial Invasibility in Eutherian Mammals

The paper identifies cis-regulatory differences in genomic sequences that explain species-specific variations in endometrial invasibility and their link to gene expression and stromal properties.