Pharmacology & ToxicologybioRxiv
Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
J. Li, Y. Fukase, Y. Shang…·B. S. Coller
This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.
DOI 10.1021/acsptsci.9b00041