Y. Shang

Coxsackievirus group B3 regulates ASS1-mediated metabolic reprogramming and promotes macrophage inflammatory polarization in viral myocarditis

This study shows CVB3 infection upregulates ASS1 through citrulline consumption, leading to metabolic reprogramming and macrophage inflammatory polarization, contributing to viral myocarditis.

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

Logic Gate Activated Lysosome Targeting DNA Nanodevice for Controlled Proteins Degradation

This paper develops a logic-gate activated lysosome targeting DNA nanodevice for controlled protein degradation and modulates T cell-mediated antitumor immunity.

Recombinant outer membrane vesicles coupled with cytokines act as high-performance adjuvants against Helicobacter pylori infection in mice

This paper shows recombinant outer membrane vesicles with cytokines enhance immune responses and H. pylori clearance in mice compared to traditional adjuvants.

CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis

This study identifies CRB3's role in navigating Rab11 vesicles to promote γTuRC assembly during ciliogenesis and its regulation of Hh and Wnt signaling in tumorigenesis.

Gliotransmission orchestrates neuronal type-specific axon regeneration

This study shows gliotransmission via adenosine signaling determines axon regeneration in specific neuronal types, with implications for CNS repair.

Intermittent fasting mitigates cognitive deficits in Alzheimer's disease via the gut-brain axis

This study shows intermittent fasting improves cognitive function in Alzheimer's mice by reducing Aβ and neuroinflammation, and through gut microbiota and metabolite changes.

Highly efficient multiplex genome editing in dicot plants using improved CRISPR/Cas systems

This study improves CRISPR/Cas9 systems for efficient gene editing in dicot plants, achieving over 80% homozygous/bi-allelic mutations in tobacco and tomato.

KRAS G12D can be targeted by potent salt-bridge forming inhibitors

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

A high throughput bispecific antibody discovery pipeline

This paper introduces a high throughput single-cell pipeline for bispecific antibody discovery, demonstrating its efficiency in identifying rare functional clones and uncovering design principles for improved immunotherapeutics.

Self-assembling SARS-CoV-2 nanoparticle vaccines targeting the S protein induces protective immunity in mice

This study develops self-assembling SARS-CoV-2 nanoparticle vaccines that induce protective immunity in mice through subcutaneous and oral administration.

Cross-neutralization antibodies against SARS-CoV-2 and RBD mutations from convalescent patient antibody libraries

Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis

This study identifies ZNF704 as a driver of breast carcinogenesis by disrupting circadian rhythms through repression of PER2 and other clock genes.

Moxifloxacin efficacy against Mycobacterium abscessus in vivo using zebrafish model

This study evaluates moxifloxacin efficacy against Mycobacterium abscessus in a zebrafish model, finding limited in vivo activity despite good in vitro results.

Specific gyrA gene mutations correlate with high prevalence of discordant levofloxacin resistance in Mycobacterium tuberculosis isolates from Beijing, China

The paper identifies specific gyrA gene mutations in Mycobacterium tuberculosis isolates that cause discordant levofloxacin resistance between molecular and phenotypic testing.

Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.

Specific Eph Receptor-Cytoplasmic Effector Signaling Mediated by SAM-SAM Domain Interactions

The paper investigates SAM-SAM domain interactions in Eph receptors and identifies SAMD5 as a new binding partner, explaining disease-related mutations.

Down-regulation of LRIG1 by miR-20a modulates gastric cancer multidrug resistance

This study identifies miR-20a/LRIG1/EGFR axis as a regulator of gastric cancer multidrug resistance and suggests it as a therapeutic target.

Gene expression profiling reveals U1 snRNA regulates cancer gene expression

This study identifies 916 differentially expressed genes in rat cells over-expressing U1 snRNA, with 12 enriched pathways linked to cancer.