Author

L. Colwell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Gamble· 1 shared D. Bryant· 1 shared D. Carrieri· 1 shared D. Doughty· 1 shared D. Kern· 1 shared E. Bixby· 1 shared H. K. Wayment-Steele· 1 shared J. Dang· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBioengineering

C. Gamble

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Author profile →

2 papers

Recent·Most cited

Prediction of multiple conformational states by combining sequence clustering with AlphaFold2

H. K. Wayment-Steele, S. Ovchinnikov, L. Colwell, D. Kern

The paper uses sequence clustering with AlphaFold2 to predict conformational states of proteins and identifies mutations that switch between states.

bioRxiv · Oct 17, 2022 · PreprintBiochemistry

Machine Learning Optimization of Photosynthetic Microbe Cultivation and Recombinant Protein Production

C. Gamble, D. Bryant, D. Carrieri, E. Bixby, J. Dang, J. Marshall, D. Doughty, L. Colwell, M. Berndl, J. Roberts, M. Frumkin

This study uses machine learning to optimize culture conditions for producing therapeutic proteins in spirulina, doubling production and improving volumetric productivity by 70-100%.

bioRxiv · Aug 6, 2021 · PreprintBioengineering