J. Marshall

Advancing Tolerogenic Immunotherapy: A Multi-Epitope Vaccine Design Targeting the CYP2D6 Autoantigen in Autoimmune Hepatitis Through Immuno-Informatics

This paper designs a multi-epitope tolerogenic vaccine targeting CYP2D6 for autoimmune hepatitis using immuno-informatics, showing it induces IL-10 and programs dendritic cells toward a tolerogenic state.

Impact of Infectious Diseases on Wild Bovidae Populations in Thailand: Insights from Population Modelling and Disease Dynamics

This study models the impact of six infectious diseases on a gaur population over 100 years, finding that chronic infections cause the greatest population decline, while acute infections have minimal impact.

Mapping threatened Thai bovids provides opportunities for improved conservation outcomes in Asia

The paper maps suitable habitats for five threatened bovids in Thailand and identifies conservation opportunities by analyzing protected area coverage.

B vitamin quantification in lentil seed tissues using ultra-performance liquid chromatography-selected reaction monitoring mass spectrometry

The paper quantifies B vitamin levels in lentil seed tissues across genotypes, showing tissue-specific distributions and genetic variability for breeding improvements.

Multiple rod layers increase the speed and sensitivity of vision in nocturnal reef fishes

This study investigates the function of multibank retinas in nocturnal reef fishes, finding they enhance vision speed and sensitivity in both dim and bright light.

Mitochondrial fission is increased in macrophages during mROS production in response to S. pneumoniae

This study shows that mitochondrial fission in macrophages increases during mROS production in response to S. pneumoniae, linked to reduced oxidative phosphorylation and enhanced bacterial killing.

Colour Vision in Stomatopod Crustaceans: more questions than answers

This study investigates colour vision in mantis shrimps, finding they can distinguish colours despite having extensive spectral sensitivities and challenging previous assumptions about their colour processing mechanisms.

Machine Learning Optimization of Photosynthetic Microbe Cultivation and Recombinant Protein Production

This study uses machine learning to optimize culture conditions for producing therapeutic proteins in spirulina, doubling production and improving volumetric productivity by 70-100%.

The role of L-arabinose metabolism for Escherichia coli O157:H7 in edible plants

This study investigates L-arabinose metabolism in E. coli O157:H7 during plant colonization, showing gene activation and metabolic utilization of plant-derived arabinose.

Single cell transcriptomics reveal disrupted kidney filter cell-cell interactions after early and selective podocyte injury

The paper uses single-cell RNA sequencing to identify early transcriptional changes in kidney cells after podocyte injury, revealing disrupted cell-cell interactions that contribute to chronic kidney disease progression.

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

The paper identifies Fostamatinib as a potential repurposing drug for acute lung injury by reducing MUC1 protein levels in preclinical models.

Microhabitat partitioning correlates with opsin geneexpression in coral reef cardinalfishes (Apogonidae)

The paper examines how microhabitat use in cardinalfishes correlates with opsin gene expression and eye morphology, finding that habitat exposure influences opsin expression and eye size.

Neoteny in visual system development of the spotted unicornfish, Naso brevirostris (Acanthuridae)

The paper examines visual system development in the spotted unicornfish, finding that its visual system remains largely unchanged across developmental stages despite habitat and diet shifts.

Pathologically distinct fibroblast subsets drive inflammation and tissue damage in arthritis

The paper identifies two distinct fibroblast subsets in arthritis that drive inflammation or tissue damage, showing their unique roles in disease progression.

Overcoming evolved resistance to population-suppressing homing-based gene drives

This paper develops a mathematical model to assess resistance to CRISPR-Cas9 homing gene drives and proposes a multiplexed gRNA strategy to enhance suppression efficacy.