D. Bryant

Detection and decontamination of chronic wasting disease prions during venison processing

This study demonstrates that CWD prions can contaminate processing surfaces and be transferred to CWD-negative venison, but can be inactivated using bleach and potassium peroxymonosulfate.

Listeria adhesion protein orchestrates caveolae-mediated apical junctional remodeling of epithelial barrier for L. monocytogenes translocation

This study shows LAP promotes L. monocytogenes translocation by remodeling epithelial junctions via caveolae-mediated endocytosis.

PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.

This study identifies ARF6 as a critical vulnerability in PTEN-deficient ovarian cancer, showing its role in integrin-dependent invasion and its inverse association with patient outcomes.

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

The paper identifies 14q32 cluster miRNAs as key regulators of transcriptional differences between IGHV-mutated and unmutated CLL, with miR-409-3p and miR-411-3p repressing GAB1.

Machine Learning Optimization of Photosynthetic Microbe Cultivation and Recombinant Protein Production

This study uses machine learning to optimize culture conditions for producing therapeutic proteins in spirulina, doubling production and improving volumetric productivity by 70-100%.

RAL GTPases mediate EGFR-driven intestinal stem cell hyperproliferation and tumourigenesis.

This study shows RAL GTPases activate EGFR/MAPK signaling in intestinal stem cells, promoting proliferation and tumorigenesis, but are independent of oncogenic RAS.

Spatial enrichment of phosphoinositide metabolism is a molecular switch to promote metastasis.

This study identifies IQSEC1 variants that spatially regulate phosphoinositide metabolism to switch cell behavior from growth to invasion, with implications for metastasis.

Genome and time-of-day transcriptome of Wolffia australiana link morphological extreme minimization with un-gated plant growth

This study analyzes the genome and time-of-day transcriptome of Wolffia australiana to link its extreme morphological minimization with reduced circadian regulation and continuous growth.

Host population diversity as a driver of viral infection cycle in wild populations of green sulfur bacteria with long standing virus-host interactions

This study examines viral infection dynamics in green sulfur bacteria, finding that multiple viruses, including lysogenic ones, co-infect host populations and that host diversity may influence the lytic/lysogenic switch.

Target Capture Sequencing Unravels Rubus Evolution

This study uses target capture sequencing to estimate the phylogeny of Rubus species, revealing subgeneric paraphyly and historical biogeographic patterns.

Exceptional subgenome stability and functional divergence in allotetraploid teff, the primary cereal crop in Ethiopia

This study presents a chromosome-scale genome assembly of teff and reveals exceptional subgenome stability and functional divergence, which may contribute to its resilience and diversification.

Count does not recover major events of gene flux in real biological data

The paper tests Count's ability to detect mass gene transfer events and finds it biases towards uniform distribution rather than sporadic acquisition and differential loss.