L. Csanady

The structures of protein kinase A in complex with CFTR: mechanisms of phosphorylation and reversible activation

This study presents cryo-EM structures of PKA-C bound to CFTR, revealing mechanisms of phosphorylation and reversible activation through catalytic interactions and conformational flexibility.

Structural determinants of protein kinase A essential for CFTR channel activation

This paper identifies structural determinants of PKA-C essential for CFTR activation, showing two distinct regions mediate reversible and irreversible activation, and highlights the role of PKA-C myristoylation in this process.

Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein

The paper estimates the non-hydrolytic closing rate of WT CFTR by comparing it to mutants with disrupted ATP hydrolysis, revealing how specific mutations affect this rate.

Molecular pathology of a cystic fibrosis mutation is explained by loss of a hydrogen bond

The paper identifies a hydrogen bond critical for CFTR gating and shows its loss explains the gating defect in the R117H mutation.