Metastatic potential in clonal melanoma cells is driven by a rare, early-invading subpopulation
A. Kaur, L. Cuenca, K. Kiani, G. Busch, D. Fingerman, M. C. Dunagin, J. Li, I. Dardani, E. M. Sanford, J. Pemberton, Y. Goyal, A. T. Weeraratna, M. Herlyn, A. Raj
The paper identifies a rare invasive subpopulation of melanoma cells that drives metastasis, independent of environment, through non-genetic gene expression fluctuations.
bioRxiv · Apr 17, 2022 · PreprintCancer Biology