Author

L. Daruka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

B. Kintses· 3 shared C. Pal· 3 shared B. M. Vasarhelyi· 2 shared B. Papp· 2 shared D. Balogh· 2 shared E. Ari· 2 shared G. Grezal· 2 shared M. Szamel· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

B. Kintses

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3 papers

Recent·Most cited

Antibiotics of the future are prone to resistance in Gram-negative pathogens

L. Daruka, M. S. Czikkely, P. Szili, Z. Farkas, D. Balogh, G. Grezal, E. Maharramov, T.-H. Vu, L. Sipos, S. Juhasz, A. Dunai, A. Daraba, M. Szamel, T. Sari, T. Stirling, , C. Pal

This study shows new antibiotics are as likely to face resistance as existing ones in Gram-negative bacteria, highlighting the need for narrow-spectrum therapies.

bioRxiv · Jul 23, 2023Microbiology

Chemical-genetic profiling reveals cross-resistance and collateral sensitivity between antimicrobial peptides

B. Kintses, P. K. Jangir, G. Fekete, M. Szamel, O. Mehi, R. Spohn, L. Daruka, A. Martins, A. Hosseinnia, A. Gagarinova, S. Kim, S. Phanse, B. Csörgö, A. Györkei, E. Ari, , B. Papp

This study uses a chemical-genetic approach to analyze resistance determinants of E. coli to 15 AMPs, revealing cross-resistance and collateral sensitivity patterns.

bioRxiv · Feb 8, 2019 · PreprintMicrobiology

Antibiotic usage promotes the evolution of resistance against gepotidacin, a novel multi-targeting drug

P. Szili, G. Draskovits, T. Revesz, F. Bogar, D. Balogh, T. Martinek, L. Daruka, R. Spohn, B. M. Vasarhelyi, M. Czikkely, B. Kintses, G. Grezal, G. Ferenc, C. Pal, A. Nyerges

This study shows that antibiotic use promotes resistance evolution against gepotidacin, a multi-targeting antibiotic, through mutations that also confer resistance to fluoroquinolones.

bioRxiv · Dec 13, 2018Microbiology