Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of antibiotic resistance by MCR-1 plasmid acquisition
P. K. Jangir, Q. Yang, L. P. Shaw…·C. MacLean
The paper shows pre-existing lpxC polymorphisms in E. coli enhance the evolution of colistin resistance via MCR-1 plasmid acquisition through positive epistasis.