L. E. Jansen

Spt6 is a maintenance factor for centromeric CENP-A

This study shows Spt6 maintains centromeric CENP-A by preventing its loss during transcription, in both Drosophila and human cells.

Complementary, Semi-automated Methods for Creating Multi-dimensional, PEG-based Biomaterials

This study presents semi-automated methods for creating tunable, PEG-based biomaterials that mimic ECM features, enabling high-throughput screening of cell responses.

Anomalous Diffusion as a Descriptive Model of Cell Migration

This study shows that an anomalous diffusion model better describes cell migration in 2D and 3D environments than the persistent random walk model, especially in subdiffusive conditions.

A Biomaterial Screening Approach to Reveal Microenvironmental Mechanisms of Drug Resistance

This paper screens drug responses across biomaterial platforms to identify ECM-mediated mechanisms of resistance to RTK-targeted therapies and finds that MEK phosphorylation is a key factor.

Control of Thiol-Maleimide Reaction Kinetics in PEG Hydrogel Networks

This study investigates methods to control thiol-maleimide reaction kinetics in PEG hydrogels to improve uniformity and cell viability.

Zwitterionic hydrogels modulate the foreign body response in a modulus-dependent manner

This study shows that modulus and zwitterion content independently affect the foreign body response to soft hydrogels, with higher modulus increasing inflammation.