S. Peyton

Live Cell Lineage Tracing of Dormant Cancer Cells

This paper develops a live cell lineage tracing method to track dormant cancer cells in vitro, revealing that dormancy is influenced by both intrinsic and extrinsic factors.

Cavitation Induced Fracture of Intact Brain Tissue

This study measures fracture energy in intact brain tissue using needle-induced cavitation and hydraulic fracture models, finding values between 1.5 to 8.9 J/m2 depending on location and model.

Control of Astrocyte Quiescence and Activation in a Synthetic Brain Hydrogel

This paper introduces a synthetic brain hydrogel that maintains astrocyte quiescence and allows controlled activation through specific ECM domains and stimuli.

Tumor cell-organized fibronectin is required to maintain a dormant breast cancer population

This study identifies tumor cell-organized fibronectin as essential for maintaining dormant breast cancer populations through in vitro experiments.

2D or 3D? How in vitro cell motility is conserved across dimensions, and predicts in vivo invasion

The paper compares 2D and 3D in vitro cell motility models to assess their predictive power for in vivo cell invasion, finding positive correlations between 2D metrics and 3D migration, and a negative correlation between 3D invasion and glioblastoma in vivo.

An omentum-inspired 3D PEG hydrogel for identifying ECM drivers of drug resistant ovarian cancer

This study develops a 3D omentum-inspired hydrogel to better model ovarian cancer drug resistance, identifying collagen 3 as a potential driver of Paclitaxel resistance.

Applicability of Drug Response Metrics for Cancer Studies using Biomaterials

This paper clarifies inconsistent drug response metrics in cancer biomaterial studies and provides best practices for their reporting.

Complementary, Semi-automated Methods for Creating Multi-dimensional, PEG-based Biomaterials

This study presents semi-automated methods for creating tunable, PEG-based biomaterials that mimic ECM features, enabling high-throughput screening of cell responses.

Anomalous Diffusion as a Descriptive Model of Cell Migration

This study shows that an anomalous diffusion model better describes cell migration in 2D and 3D environments than the persistent random walk model, especially in subdiffusive conditions.

A Biomaterial Screening Approach to Reveal Microenvironmental Mechanisms of Drug Resistance

This paper screens drug responses across biomaterial platforms to identify ECM-mediated mechanisms of resistance to RTK-targeted therapies and finds that MEK phosphorylation is a key factor.

Control of Thiol-Maleimide Reaction Kinetics in PEG Hydrogel Networks

This study investigates methods to control thiol-maleimide reaction kinetics in PEG hydrogels to improve uniformity and cell viability.

Zwitterionic hydrogels modulate the foreign body response in a modulus-dependent manner

This study shows that modulus and zwitterion content independently affect the foreign body response to soft hydrogels, with higher modulus increasing inflammation.