Author

P. Heun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell type annotation· 2 Organism:Drosophila· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. A. Jeyaprakash· 3 shared B. Medina-Pritchard· 3 shared E. Anselm· 2 shared J. Rappsilber· 2 shared J. Zou· 2 shared V. Lazou· 2 shared A. Huang· 1 shared A. Imhof· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

A. A. Jeyaprakash

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4 papers

Recent·Most cited

Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance

R. Thamkachy, B. Medina-Pritchard, S. H. Park, C. G. Chiodi, J. Zou, M. de la Torre-Barranco, K. Shimanaka, M. A. Abad, C. Gallego Paramo, R. Feederle, E. Ruksenaite, P. Heun, O. R. Davies, J. Rappsilber, D. Schneidman-Duhovny, , A. A. Jeyaprakash

This study characterizes the structure of the Mis18 complex and identifies structural determinants essential for its assembly and centromere maintenance.

bioRxiv · Nov 8, 2021 · PreprintCell Biology

Structural Basis for CAL1-Mediated Centromere Maintenance

B. Medina-Pritchard, V. Lazou, J. Zou, O. Byron, J. Rappsilber, P. Heun, A. A. Jeyaprakash

This study reveals how Drosophila CAL1 targets CENP-A to centromeres via structural interactions with CENP-A/H4 and CENP-C, bypassing the need for the Mis18 complex.

bioRxiv · Aug 2, 2019 · PreprintBiochemistry

Spt6 is a maintenance factor for centromeric CENP-A

G. O. Bobkov, A. Huang, S. J. van den Berg, S. Mitra, E. Anselm, V. Lazou, S. Schunter, R. Federle, A. Imhof, A. Lusser, L. E. Jansen, P. Heun

This study shows Spt6 maintains centromeric CENP-A by preventing its loss during transcription, in both Drosophila and human cells.

bioRxiv · Feb 25, 2019Cell Biology

Epigenetic inheritance of centromere identity in a heterologous system

V. Roure, B. Medina-Pritchard, E. Anselm, A. A. Jeyaprakash, P. Heun

This study uses a heterologous system to investigate how dCENP-A is propagated in human cells, identifying key interactions between dCENP-C, CAL1, and dCENP-A for epigenetic centromere inheritance.

bioRxiv · Feb 25, 2019 · PreprintCell Biology