Integrated analysis reveals FOXA1 and Ku70/Ku80 as direct targets of ivermectin in prostate cancer
S. Lv, Z. Wu, M. Luo, Y. Zhang, J. Zhang, L. E. Pascal, Z. Wang, Q. Wei
This study identifies FOXA1 and Ku70/Ku80 as direct targets of ivermectin in prostate cancer, showing it induces cell cycle arrest, apoptosis, and synthetic lethality through chromatin accessibility reduction and DNA repair impairment.
Cell Death & Disease · Sep 1, 2022Peer-reviewedCancer Biology