Q. Wei

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

Conditioned immunological memory: implication for cognition of immune cells

This study demonstrates that immune cells can undergo classical conditioning, forming associations between hapten analogues and conjugates, leading to conditioned immunological memory and humoral immunosuppression.

Single cell transcriptome profiling reveals pathogenesis of Bullous Pemphigoid

This study uses single-cell transcriptomics to identify functional changes in skin and blood cells during Bullous Pemphigoid, revealing key pathways and cell interactions involved in disease progression.

A modular toolkit for environmental Rhodococcus, Gordonia, and Nocardia enables complex metabolic manipulation.

The paper develops a modular genetic toolkit for environmental Actinomycetes, enabling metabolic engineering and complex circuit design in Rhodococcus, Nocardia, and Gordonia.

A Ratiometric Nonfluorescent CRISPR Assay Utilizing Cas12a-Induced Plasmid Supercoil Relaxation

The paper develops a ratiometric CRISPR assay using Cas12a-induced plasmid supercoil relaxation for ultrasensitive, label-free detection of DNA targets.

Rapid Adeno-Associated Virus Genome Quantification with Amplification-Free CRISPR-Cas12a

The paper develops a CRISPR-based assay to rapidly and accurately quantify AAV genome titers, enabling efficient manufacturing of rAAV vectors.

Glucocorticoid receptor activation reprograms NK cells to drive AREG-mediated immunosuppression in skin cancer

This study identifies glucocorticoid receptor activation in NK cells as a mechanism driving AREG-mediated immunosuppression in skin cancer, with therapeutic implications.

Alstrom Syndrome protein Alms1 is required for maintaining meiotic centriole engagement in spermatocytes of Drosophila

This study shows that Alms1 is essential for maintaining centriole engagement in Drosophila spermatocytes, with implications for understanding Alstrom Syndrome pathogenesis.

Cep290 is cooperatively maintained at basal body by Cep131-Cep162 and Cby-Fam92 modules

This study identifies two modules, Cep131-Cep162 and Cby-Fam92, that cooperatively maintain Cep290 at the basal body and initiate ciliogenesis.

Thermoplasmonic modulation of cardiomyocytes activity with local temperature read-out

This paper develops a light-based method to modulate cardiomyocyte beating rate using near-infrared plasmonic heating and measures local temperature changes with silica-coated quantum dots.

Skin permeable polymer for noninvasive transdermal insulin delivery

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

Integrated analysis reveals FOXA1 and Ku70/Ku80 as direct targets of ivermectin in prostate cancer

This study identifies FOXA1 and Ku70/Ku80 as direct targets of ivermectin in prostate cancer, showing it induces cell cycle arrest, apoptosis, and synthetic lethality through chromatin accessibility reduction and DNA repair impairment.

A library of promoter-gfp fusion reporters for studying systemic expression pattern of cyclic-di-GMP metabolism-related genes in Pseudomonas aeruginosa

The paper constructs a promoter-GFP fusion reporter library to study the systemic expression patterns of 41 c-di-GMP metabolism-related genes in Pseudomonas aeruginosa under various growth conditions.

Integrating inflammatory biomarker analysis and artificial intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis

The paper identifies potential drug targets for intestinal fibrosis by combining image-based morphology analysis with AI and inflammatory biomarker measurements.

Social Regulation of Egg Size Plasticity in the Honey Bee is Mediated by Cytoskeleton Organizer Rho1

This study identifies Rho1 as a key regulator of egg size plasticity in honey bees, showing queens adjust egg size based on colony size through molecular changes involving energy metabolism and cytoskeleton functions.

Machine Learning Classification Reveals Robust Morphometric Biomarker of Glial and Neuronal Arbors

The paper uses machine learning to classify neuronal and glial arbors based on morphometric features, identifying a robust biomarker, ABEL, that distinguishes them across species and brain regions.

Protein Kinase C Delta Regulates Mononuclear Phagocytes and Hinders Response to Immunotherapy in Cancer

This study shows that PKCδ in mononuclear phagocytes suppresses antitumor immunity and response to immunotherapy by reprogramming macrophages and dendritic cells.

Mass extravasation and tubular uptake of red blood cells results in toxic injury to the tubules during kidney ischemia from venous clamping

This study shows that venous clamping in rats causes severe kidney tubular injury due to red blood cell extravasation and uptake, which is absent in blood-free kidneys.

Mechanoaccumulation of non-muscle myosin IIB during mitosis requires its translocation activity

This study shows that during mitosis, NMIIB mechanoaccumulation at the cell cortex requires its motor activity, not just actin-binding function, and is mediated by RhoA and ROCK signaling.

Lupus Gut Microbiota Transplants Cause Autoimmunity and Inflammation

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.

Neuromodulation of Behavioral Specialization: Tachykinin Signaling Inhibits Task-Specific Behavioral Responsiveness in Honeybee Workers

This study identifies tachykinin peptides as regulators of task-specific behavioral responsiveness in honeybee workers by manipulating their expression and observing behavioral outcomes.

Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

Simultaneously monitoring aquatic and riparian biodiversity using riverine water eDNA

This study assesses the effectiveness of riverine water eDNA for monitoring aquatic and riparian biodiversity, finding it effective for detecting species and bioinformation in specific conditions.

Working groups, gender and publication impact of Canada's ecology and evolution faculty

This study examines how participation in working groups and gender influence the publication impact of Canadian ecology and evolution faculty over three decades.

Addressable Nanoantennas with Cleared Hotspots for Single-Molecule Detection on a Portable Smartphone Microscope

This paper introduces NACHOS, a DNA origami-based nanoantenna system that enables single-molecule detection using a smartphone microscope, reducing costs and complexity.

Impact of glycan positioning on HIV-1 Env glycan shield density, function, and antibody recognition

This study shows how changes in individual glycan units of HIV-1 Env affect structure, function, and antibody recognition through high-resolution glycomics and molecular dynamics.

Lack of Reinfection in Rhesus Macaques Infected with SARS-CoV-2

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

Protection of Rhesus Macaque from SARS-Coronavirus challenge by recombinant adenovirus vaccine

This study shows a recombinant adenovirus vaccine protects rhesus macaques from SARS-CoV challenge by inducing immune responses and reducing lung damage.

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.