Severe and multifaceted systemic immunosuppression caused by experimental cancers of the central nervous system requires release of non-steroid soluble mediators
K. Ayasoufi, C. K. Pfaller, L. Evgin, R. H. Khadka, Z. P. Tritz, E. N. Goddery, C. E. Fain, L. T. Yokanovich, B. T. Himes, F. Jin, J. Zheng, M. R. Schuelke, M. J. Hansen, W. Tung, L. R. Pease, , A. J. Johnson
This study identifies non-steroid soluble factors released by CNS cancers and injuries that cause systemic immunosuppression by inducing thymic and splenic involution and reducing MHC class II expression.
bioRxiv · Mar 24, 2020 · PreprintImmunology