R. H. Khadka

This study identifies antigen-specific brain-resident memory T cells that expand rapidly after CNS injury or viral infection and induce neuroinflammation and peripheral immune suppression.

This study identifies microglia and perivascular macrophages as antigen-presenting cells that present MHC class I antigens to CD8 T cells, facilitating their infiltration into the brain during viral infection.

This study identifies non-steroid soluble factors released by CNS cancers and injuries that cause systemic immunosuppression by inducing thymic and splenic involution and reducing MHC class II expression.

This study shows that CD11c+ antigen-presenting cells are critical for early CD8 T cell responses against TMEV, but not for later responses, using a conditional H-2Db knockout mouse model.