J. Zheng

This study shows that an endogenous AhR ligand induces PE-like phenotypes by altering transcriptome, phosphoproteome, and vascular functions in pregnant rats and HUVECs.

This paper introduces an LED photobleaching method to enhance 3D immunofluorescence microscopy multiplexity for tumor microenvironment analysis, achieving 8-plex imaging.

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

This paper analyzes 1512 soil metagenomes to uncover genomic patterns of soil microbiomes across environmental factors and biomes, revealing shifts in microbial functions and biogeographical distributions.

This study identifies MARCH5 as a regulator of mitochondria-derived pre-peroxisomes by impeding PEX3-containing vesicle budding.

The paper quantifies how well the MWC model predicts TRPV1 activation by vanilloids, finding a small subunit position effect not seen in hemoglobin.

This study identifies senescent osteoclasts in spinal models as contributors to pain through nerve growth and vessel formation, showing their removal reduces hypersensitivity.

This study identifies TRIM72 as a host factor that restricts lyssavirus infection by promoting ubiquitination and proteasomal degradation of the viral matrix protein.

The paper identifies sphingolipids as regulators of synphilin-1 inclusion body maturation and detoxification in yeast and mammalian cells.

This study links millisecond conformational dynamics of ubiquitin to protein stability through alanine mutations affecting the C-terminal retracted state.

This study examines gut microbiome and serum metabolome changes in chronic low back pain patients with bone marrow lesions, identifying key microbial species and metabolic pathways involved.

The paper surveys antimicrobial resistance in Maryland surface waters, finding higher prevalence of beta-lactamase genes in high human impact areas.

This study identifies miR-29a/c-3p dysregulation in PE as sex-specific modulator of cytokine responses in fetal endothelial cells, with distinct effects on monolayer integrity and proliferation.

This study identifies and characterizes Salactin, an actin homolog in Haloarchaea, showing it forms dynamically unstable filaments and is involved in chromosomal segregation under low-ploidy conditions.

This study combines flexible implantable microelectronics with machine learning to achieve reliable long-term neural decoding for seizure prediction in epileptic mice.

This study identifies suppressed ferroptosis in male colorectal cancer patients with KRAS mutations, linking it to poorer survival outcomes.

This study shows SUMOylation of PTEN enhances HR repair by dephosphorylating 53BP1, promoting DNA end resection and inhibiting NHEJ.

The paper sequenced four Zygnematophyceae algal genomes to study signaling network evolution, finding expanded genes for multicellularity and environmental response.

The paper measures how RTX binding to TRPV1 subunits affects channel opening, finding each subunit contributes equally to activation energy.

This study shows USP39 promotes liver cancer by regulating alternative splicing through interaction with SRSF6/HNRNPC, identifying it as a potential therapeutic target.

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

The paper identifies multiple transcription factor perturbations that rejuvenate aged human skin fibroblasts through a Perturb-seq screen and validation of aging hallmarks.

This study identifies the mechanism of contractile ring mechanosensation and its anillin-dependent tuning during asymmetric ring closure in C. elegans embryos.

This study investigates how cold-chain conditions and disinfection methods affect SARS-CoV-2 stability, finding that low temperature and seawater increase viral survival while LED light and airflow reduce it.

STRAINS classifies cellular responses to stimuli at the tissue scale by analyzing spatiotemporal behavior using fluorescent micrographs and machine learning.

This study identifies LRP8 as a targetable vulnerability in MYCN-amplified neuroblastoma by showing its role in selenocysteine import and resistance to ferroptosis.

This study shows that trait correlations of a single protein can evolve rapidly through mutation and selection, driven by changes in protein foldability.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This paper reports the crystal structure of Rubella virus protease and demonstrates its protease and deubiquitylation activities, providing insights for antiviral drug development.

The paper identifies APE-1 as a modulator of PP1 activity in C. elegans, showing it localizes PP1 to junctions and modulates phosphatase output through its ankyrin repeats.