Author

C. K. Pfaller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. J. Johnson· 2 shared B. Sawatsky· 2 shared C. E. Fain· 2 shared E. N. Goddery· 2 shared F. Jin· 2 shared K. Ayasoufi· 2 shared K. Wittwer· 2 shared L. T. Yokanovich· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

A. J. Johnson

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Author profile →

5 papers

Recent·Most cited

Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS injury and viral infection

K. Ayasoufi, D. M. Wolf, S. L. Namen, Z. P. Tritz, F. Jin, C. K. Pfaller, E. N. Goddery, C. E. Fain, L. R. Gulbicki, R. H. Khadka, L. T. Yokanovich, M. J. Hansen, A. J. Johnson

This study identifies antigen-specific brain-resident memory T cells that expand rapidly after CNS injury or viral infection and induce neuroinflammation and peripheral immune suppression.

Brain, Behavior, and Immunity · Aug 1, 2023Peer-reviewedImmunology

Non-neutralizing antibody responses to vesicular stomatitis virus-vectored influenza A virus vaccines correlate with protection

K. Wittwer, G. Zimmer, M. Rommel, Y. Krebs, S. Rezinciuc, B. Sawatsky, C. K. Pfaller

This study shows that non-neutralizing antibodies against conserved IAV antigens like NP and M2 provide cross-protection against different IAV strains in mice.

bioRxiv · Nov 2, 2022 · PreprintImmunology

Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements

B. Tegtmeyer, G. Vieyres, D. Todt, C. Lauber, C. Ginkel, M. Engelmann, M. Herrmann, C. K. Pfaller, F. W. R. Vondran, R. Broering, E. Vafadarnejad, A.-E. Saliba, C. Puff, W. Baumgärtner, C. Miskey, , R. J. P. Brown

This study identifies temporally structured transcriptional changes in HCV-infected human hepatocytes, revealing both antiviral and pro-viral programs that may contribute to viral persistence.

bioRxiv · Feb 12, 2021Immunology

Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19

A. A. Hennrich, D. H. Banda, M. Oberhuber, A. Schopf, V. Pfaffinger, K. Wittwer, B. Sawatsky, C. Riedel, C. K. Pfaller, K.-K. Conzelmann

This paper develops a safe and effective vaccine platform using rhabdovirus replicons that present the SARS-CoV-2 RBD as VLPs, inducing strong neutralizing antibodies in mice.

bioRxiv · Oct 2, 2020 · PreprintMicrobiology

Severe and multifaceted systemic immunosuppression caused by experimental cancers of the central nervous system requires release of non-steroid soluble mediators

K. Ayasoufi, C. K. Pfaller, L. Evgin, R. H. Khadka, Z. P. Tritz, E. N. Goddery, C. E. Fain, L. T. Yokanovich, B. T. Himes, F. Jin, J. Zheng, M. R. Schuelke, M. J. Hansen, W. Tung, L. R. Pease, , A. J. Johnson

This study identifies non-steroid soluble factors released by CNS cancers and injuries that cause systemic immunosuppression by inducing thymic and splenic involution and reducing MHC class II expression.

bioRxiv · Mar 24, 2020 · PreprintImmunology