Author

L. F. T. Novaes

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Biochemistry· 1

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

B. Tong· 1 shared D. K. Nomura· 1 shared E. Zhang· 1 shared J. A. Tallarico· 1 shared J. M. McKenna· 1 shared J. N. Spradlin· 1 shared L. M. McGregor· 1 shared M. Moeller· 1 shared

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2020-2020 · peak 1/yr

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1 shared paperBiochemistry

B. Tong

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1 paper

Recent·Most cited

BiochemistrybioRxivApr 2, 2020

A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL

B. Tong, J. N. Spradlin, L. F. T. Novaes…·D. K. Nomura

This paper develops a PROTAC molecule, BT1, that selectively degrades BCR-ABL over c-ABL in leukemia cells using nimbolide as an E3 ligase recruiter, showing additional anti-proliferative effects.

DOI 10.1021/acschembio.0c00348

humanexperimental assay

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