E. Zhang

Dual Activation of MC3R and MC4R Drives Weight Loss and Reduces Food Intake in Obese Primates

This study shows that activating both MC3R and MC4R in obese primates leads to weight loss and reduced food intake, with a new dual agonist peptide showing efficacy and safety.

HRMAS 13C NMR and genome-scale metabolic modeling identify threonine as a preferred dual redox substrate for Clostridioides difficile

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

A single-cell atlas of the single versus multiple parous Hu Sheep ovary

This study constructs a single-cell atlas of Hu sheep ovaries comparing high-litter (HLS) and low-litter (LLS) sheep, identifying molecular differences in granulosa cells that affect reproductive outcomes.

Fission yeast CK1 promotes DNA double-strand break repair through both homologous recombination and non-homologous end joining

This study shows that fission yeast CK1 orthologues Hhp1 and Hhp2 promote DNA double-strand break repair through both homologous recombination and non-homologous end joining by phosphorylating substrates like Arp8.

Efficient Neutralization of SARS-CoV-2 Omicron and Other VOCs by a Broad Spectrum Antibody 8G3

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes

The paper investigates the structure of insulin granule cores and shows that their size reduction in type-2 diabetes correlates with impaired insulin secretion.

Comprehensive Evaluation of ACE2-Fc Combination with Neutralization Antibody on Broad Protection against SARS-CoV-2 and Its Variants

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

Tracing boundaries in Eastern Antarctica: Multi-scale drivers of soil microbial communities across the hyperarid Vestfold Hills

This study applies Gradient Forest modelling to Antarctic soil microbiomes, identifying moisture as a key driver of microbial community composition and highlighting vulnerable taxa under climate change.

A Safe and Effective Mucosal RSV Vaccine Consisting of RSV Phosphoprotein and Flagellin Variant

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.

Mechanically Matched Silicone Brain Implants Reduce Brain Foreign Body Response

This study introduces mechanically matched silicone brain implants that reduce the foreign body response compared to traditional implants.

Screening of Cultivars for Tissue Culture Response and Establishment of Genetic Transformation in a High-yielding and Disease-resistant Cultivar of Theobroma cacao

The paper establishes tissue culture and genetic transformation methods for a high-yielding, disease-resistant Theobroma cacao cultivar and identifies factors improving T-DNA delivery and somatic embryogenesis.

A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL

This paper develops a PROTAC molecule, BT1, that selectively degrades BCR-ABL over c-ABL in leukemia cells using nimbolide as an E3 ligase recruiter, showing additional anti-proliferative effects.

Effects of artificially introduced Enterococcus faecalis strains in experimental necrotizing enterocolitis

This study introduces E. faecalis strains into neonatal rats and finds that some strains increase necrotizing enterocolitis pathology.

Biodistribution and inflammatory response of intracranial delivery of scintillating nanoparticles

This study investigates the biodistribution and immune response of scintillating nanoparticles after localized injection into the cerebral cortex.

Extreme niche partitioning promotes a remarkably high diversity of soil microbiomes across eastern Antarctica.

This study analyzes soil microbiomes in eastern Antarctica to understand community structure and diversity, finding that bacterial communities show strong niche partitioning and higher diversity compared to eukaryotic and archaeal communities.