Author

L. Goers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

c. F. lesser· 3 shared P. S. Mitchell· 2 shared R. E. Vance· 2 shared A. Sandstrom· 1 shared A. Y. Lee· 1 shared E. A. Turcotte· 1 shared E. W. Mu· 1 shared I. Rauch· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

c. F. lesser

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation

L. Goers, K. Kim, P. J. Canning, T. C. Stedman, X. Mou, N. Heinz Ernst, J. Coers, c. F. lesser

This study shows that Shigella IpaH9.8 inhibits GBP1-dependent LPS release from intracellular bacteria, preventing caspase-4 activation and pyroptosis.

bioRxiv · Nov 14, 2022 · PreprintMicrobiology

NAIP-NLRC4-deficient mice are susceptible to shigellosis

P. S. Mitchell, J. L. Roncaioli, E. A. Turcotte, L. Goers, R. A. Chavez, A. Y. Lee, C. F. Lesser, I. Rauch, R. E. Vance

This study shows that NAIP-NLRC4-deficient mice are susceptible to Shigella infection, mimicking human shigellosis, and reveals that inflammasome-mediated cell death protects against the disease.

bioRxiv · May 16, 2020Microbiology

Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

A. Sandstrom, P. S. Mitchell, L. Goers, E. W. Mu, C. F. Lesser, R. E. Vance

The paper identifies proteasome-mediated degradation of NLRP1B as a mechanism by which two distinct pathogen enzymes activate the inflammasome.

bioRxiv · Nov 6, 2018Immunology