Author

L. Holt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Animal Behavior & Cognition· 1 Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:yeast· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

B. Korona· 1 shared C. Chillakuri· 1 shared F. Chang· 1 shared G. Poterewicz· 1 shared J. Choi· 1 shared J. Kayser· 1 shared J. Lemiere· 1 shared M. Delarue· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperBiochemistry

B. Korona

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

From small to tall: breed-varied household pet dogs can be trained to detect Parkinson's Disease

L. Holt, S. V. Johnston

This study trains dogs to detect Parkinson's Disease through sebum samples, achieving 89% sensitivity and 87% specificity in distinguishing PD-positive from PD-negative samples.

bioRxiv · Jan 29, 2024Animal Behavior & Cognition

Control of nuclear size by osmotic forces in Schizosaccharomyces pombe

J. Lemiere, P. Real-Calderon, L. Holt, T. Fai, F. Chang

This study shows that nuclear size in fission yeast is controlled by osmotic forces, with macromolecule concentration dictating the nuclear-to-cell volume ratio.

bioRxiv · Dec 5, 2021Biophysics

The SCWISh network is essential for survival under mechanical pressure.

M. Delarue, G. Poterewicz, O. Hoxha, J. Choi, W. Yoo, J. Kayser, L. Holt, O. Hallatschek

The paper identifies a mechanosensitive pathway, SCWISh, essential for yeast survival under mechanical pressure by integrating signals from the SMuSh and CWI pathways.

Proceedings of the National Academy of Sciences · Nov 29, 2017Peer-reviewedCell Biology

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

R. Suckling, B. Korona, P. Whiteman, C. Chillakuri, L. Holt, P. Handford, S. Lea

The paper presents structures of Notch ligands and functional assays showing that membrane recognition via the C2 domain is critical for Notch signaling, with mutations affecting this process leading to disease.

bioRxiv · Jan 18, 2017Biochemistry