Author

S. Lea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 3 Research Focus:protein structure prediction· 3 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

S. Johnson· 3 shared J. Deme· 2 shared L. Kuhlen· 2 shared A. Zeitler· 1 shared B. Korona· 1 shared C. Chillakuri· 1 shared C. M. Tang· 1 shared E. Furlong· 1 shared

Activity by Year

2017-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersMicrobiology

S. Johnson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The role of toxin:antitoxin systems and insertion sequences in the loss of virulence in Shigella sonnei

J. E. Martyn, G. Pilla, S. Hollingshead, M. Lobanovska, K. S. Winther, S. Lea, G. McVicker, C. M. Tang

This study shows that plasmid loss, mediated by insertion sequences and influenced by toxin:antitoxin systems, is the main cause of avirulence in Shigella sonnei.

bioRxiv · Aug 10, 2020 · PreprintMicrobiology

Structure of the bacterial flagellar rotor MS-ring: a minimum inventory/maximum diversity system

S. Johnson, Y. H. Fong, J. Deme, E. Furlong, L. Kuhlen, S. Lea

This study presents the structure of the Salmonella MS-ring, revealing symmetry variation that explains its role in flagellar function.

bioRxiv · Jul 30, 2019 · PreprintMicrobiology

The structure of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR-fold

M. Reichhardt, V. Loimaranta, S. Lea, S. Johnson

The paper determines the structure of SALSA/DMBT1 SRCR domains and identifies a conserved dual cation binding mechanism for ligand recognition in SRCR proteins.

bioRxiv · Jul 21, 2019Biochemistry

The flagellar substrate specificity switch protein FlhB assembles onto the extra-membrane export gate to regulate type three secretion

L. Kuhlen, S. Johnson, A. Zeitler, S. Baurle, J. Deme, R. Debo, J. Fisher, S. Wagner, S. Lea

The paper determines the structure of the FlhB/SctU switch protein in the type three secretion system export gate and shows its role in regulating secretion specificity.

bioRxiv · Jul 4, 2019 · PreprintMicrobiology

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

R. Suckling, B. Korona, P. Whiteman, C. Chillakuri, L. Holt, P. Handford, S. Lea

The paper presents structures of Notch ligands and functional assays showing that membrane recognition via the C2 domain is critical for Notch signaling, with mutations affecting this process leading to disease.

bioRxiv · Jan 18, 2017Biochemistry