Pharmacology & ToxicologybioRxiv
Proteolytic cleavage of the extracellular domain affects signaling of parathyroid hormone receptor 1
C. Klenk, L. Hommers, M. J. Lohse
This study identifies the cleavage site of the PTH1R extracellular domain and shows that proteolytic cleavage alters receptor signaling specificity by reducing Gs activation and increasing Gq activation.
DOI 10.3389/fendo.2022.839351