Author

M. J. Lohse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

U. Zabel· 2 shared A. B. Tobin· 1 shared A. R. Taddei· 1 shared A. Roman· 1 shared B. Poehl· 1 shared C. Klenk· 1 shared C. Pellegrini· 1 shared E. Charlesworth· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPharmacology & Toxicology

U. Zabel

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3 papers

Recent·Most cited

Proteolytic cleavage of the extracellular domain affects signaling of parathyroid hormone receptor 1

C. Klenk, L. Hommers, M. J. Lohse

This study identifies the cleavage site of the PTH1R extracellular domain and shows that proteolytic cleavage alters receptor signaling specificity by reducing Gs activation and increasing Gq activation.

bioRxiv · Dec 16, 2021Pharmacology & Toxicology

Functional modulation of PTH1R activation and signalling by RAMP2

K. Nemec, H. Schihada, G. Kleinau, U. Zabel, E. O. Grushevskyi, P. Scheerer, M. J. Lohse, I. Maiellaro

This study shows RAMP2 modulates PTH1R activation and signalling, enhancing Gi3 sensitivity and β-arrestin2 recruitment in a ligand-dependent manner.

bioRxiv · Dec 8, 2021 · PreprintPharmacology & Toxicology

One gene - two proteins: The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration.

F. Petragnano, I. Fasciani, Z. Wang, R. Edwards, N. Telugu, I. Pietrantoni, U. Zabel, H. Zauber, M. Grieben, M. E. Terzenidou, J. Di Gregorio, C. Pellegrini, S. Santini, A. R. Taddei, B. Poehl, , R. Maggio

The paper shows that the C-terminal fragment of the M2 muscarinic receptor localizes to mitochondria and regulates cell respiration, independent of its canonical GPCR function.

bioRxiv · Apr 13, 2021Cell Biology