Author

L. Jaroszewski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:virus· 3 Research Focus:host-pathogen & immune response· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Godzik· 4 shared A. Alisoltani· 3 shared M. Iyer· 2 shared M. Sedova· 2 shared A. Iranzadeh· 1 shared A. JoachimiakiD· 1 shared G. MinasoviD· 1 shared G. Wiersum· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersEvolutionary Biology

A. Godzik

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Increased frequency of recurrent in-frame deletions in new expanding lineages of SARS CoV-2 reflects immune selective pressure

A. Alisoltani, L. Jaroszewski, M. Iyer, A. Iranzadeh, A. Godzik

The paper identifies an increase in in-frame deletions in SARS-CoV-2 lineages, suggesting immune selective pressure as a driving force.

bioRxiv · Jul 4, 2021 · PreprintEvolutionary Biology

The interplay of SARS-CoV-2 evolution and constraints imposed by the structure and functionality of its proteins

L. Jaroszewski, M. Iyer, A. Alisoltani, M. Sedova, A. Godzik

The paper analyzes SARS-CoV-2 mutations in relation to protein structure and function, finding that foldability and functional conservation drive evolutionary patterns.

bioRxiv · Aug 10, 2020Evolutionary Biology

The crystal structure of nsp10-nsp16 heterodimer from SARS CoV-2 in complex with S-adenosylmethionine

M. Rosas Lemus, G. Minasov, L. Shuvalova, N. L. Inniss, O. Kiryukhina, G. Wiersum, Y. Kim, R. Jedrzejczak, N. I. Maltseva, M. Endres, L. Jaroszewski, A. Godzik, A. Joachimiak, K. J. Satchell

The paper determines the crystal structure of the SARS-CoV-2 nsp10-nsp16 heterodimer complex with S-adenosylmethionine at 1.80 Å resolution, revealing its role in viral mRNA capping and immune evasion.

bioRxiv · Apr 17, 2020 · PreprintBiochemistry

Large scale analysis of smoking-induced changes in the tumor immune microenvironment

A. Alisoltani, X. Qiu, L. Jaroszewski, M. Sedova, Z. Li, A. Godzik

This study analyzes smoking-induced changes in the tumor immune microenvironment across ten cancer types using TCGA data, finding increased plasma cells and altered immune cell ratios linked to survival outcomes, with stronger effects in female smokers.

bioRxiv · Mar 6, 2020 · PreprintCancer Biology