Author

K. J. Satchell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:drug response / drug discovery· 3 Organism:virus· 3 Research Focus:host-pathogen & immune response· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

G. MinasoviD· 6 shared L. ShuvalovaiD· 4 shared N. L. Inniss· 3 shared M. Rosas-Lemus· 2 shared O. Kiryukhina· 2 shared A. B. Dalia· 1 shared A. Bolotokova· 1 shared A. D. Mesecar· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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6 shared papersMicrobiology

G. MinasovORCID

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Structure of the Monkeypox profilin-like protein A42R reveals potential function differences from cellular profilins

G. Minasov, N. L. Inniss, L. Shuvalova, W. F. Anderson, K. J. Satchell

The paper reports the x-ray structure of the MPXV protein A42R, revealing structural differences from cellular profilins that suggest distinct functional properties.

bioRxiv · Aug 7, 2022 · PreprintMicrobiology

Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2'-O-methyl transfer by SARS-CoV-2 nsp16

G. Minasov, M. Rosas-Lemus, L. Shuvalova, N. L. Inniss, J. S. Brunzelle, C. M. Daczkowski, P. Hoover, A. D. Mesecar, K. J. Satchell

Science Signaling · Jun 29, 2021Peer-reviewedMicrobiology

The ChiS-family DNA-binding domain contains a cryptic helix-turn-helix variant

C. A. Klancher, G. Minasov, R. Podicheti, D. B. Rusch, T. N. Dalia, K. J. Satchell, M. B. Neiditch, A. B. Dalia

The paper determines the crystal structure of the ChiS DNA-binding domain in Vibrio cholerae, revealing a novel helix-sheet-helix variant of the HTH domain and its role in DNA binding.

mBio · Apr 27, 2021Peer-reviewedMicrobiology

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

K. Devkota, M. Schapira, S. Perveen, A. Khalili Yazdi, F. Li, I. Chau, P. Ghiabi, T. Hajian, P. Loppnau, A. Bolotokova, K. J. Satchell, K. Wang, D. Li, J. Liu, D. Smil, , M. Vedadi

This paper identifies SAM competitive inhibitors of SARS-CoV-2 nsp14 methyltransferase and characterizes their mechanism, guiding the development of selective bi-substrate inhibitors.

bioRxiv · Feb 19, 2021Biochemistry

Structure of SARS-CoV-2 2'-O-methyltransferase heterodimer with RNA Cap analog and sulfates bound reveals new strategies for structure-based inhibitor design

M. Rosas-Lemus, G. Minasov, L. Shuvalova, N. Inniss, O. Kiryukhina, J. Brunzelle, K. J. Satchell

The paper determines the structure of SARS-CoV-2 nsp16/nsp10 2'-O-methyltransferase complex with various ligands, identifying potential sites for antiviral inhibitor design.

Science Signaling · Sep 29, 2020Peer-reviewedMicrobiology

The crystal structure of nsp10-nsp16 heterodimer from SARS CoV-2 in complex with S-adenosylmethionine

M. Rosas Lemus, G. Minasov, L. Shuvalova, N. L. Inniss, O. Kiryukhina, G. Wiersum, Y. Kim, R. Jedrzejczak, N. I. Maltseva, M. Endres, L. Jaroszewski, A. Godzik, A. Joachimiak, K. J. Satchell

The paper determines the crystal structure of the SARS-CoV-2 nsp10-nsp16 heterodimer complex with S-adenosylmethionine at 1.80 Å resolution, revealing its role in viral mRNA capping and immune evasion.

bioRxiv · Apr 17, 2020 · PreprintBiochemistry

The Cyclic AMP Receptor Protein Regulates Quorum Sensing and Global Gene Expression in Yersinia pestis During Planktonic Growth and Growth in Biofilms

J. T. Ritzert, G. Minasov, R. Embry, M. J. Schipma, K. J. Satchell

This study identifies Crp-regulated genes in Y. pestis during planktonic and biofilm growth, revealing its role in quorum sensing, carbon metabolism, and virulence.

mBio · Dec 24, 2019Peer-reviewedMicrobiology

Inhibition of tumor growth by a novel engineered chimeric toxin that cleaves activated mutant and wild-type RAS

V. Vidimar, G. L. Beilhartz, M. Park, M. Biancucci, M. B. Kieffer, D. R. Gius, R. A. Melnyk, K. J. Satchell

This paper develops a chimeric toxin that cleaves both mutant and wild-type RAS, reducing tumor burden in mouse models.

bioRxiv · Dec 17, 2019Cancer Biology