BiochemistrybioRxiv
Functional and structural asymmetry suggest a unifying principle for catalysis in integral membrane-bound pyrophosphatases
J. Strauss, C. Wilkinsion, K. Vidilaseris…·A. Goldman
This study presents the first structure of a K+-independent M-PPase and shows asymmetric and time-dependent substrate binding, proposing a unified model for ion pumping and energy coupling in M-PPases.
DOI 10.1038/s44319-023-00037-x