Cell BiologybioRxiv
TSC-Insensitive Rheb Mutations Induce Oncogenic Transformation Through a Combination of Hyperactive mTORC1 Signalling and Metabolic Reprogramming
C. G. Proud, S. P. De Poi, J. Xie…·T. J. Sargeant
This study identifies two Rheb mutants that drive oncogenic transformation via hyperactive mTORC1 signaling and distinct metabolic reprogramming pathways.
DOI 10.1007/s00018-021-03825-7