W. Pan

Genetic variation in the species Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis

This study identifies natural heat resilience factors in Arabidopsis thaliana that enhance meiotic stability under heat stress, with implications for crop breeding.

Phosphorylation-induced flexibility of proto-oncogenic Bcl3 regulates transcriptional activation by NF-κB p52 homodimer

This study shows phosphorylation at Ser366 enhances Bcl3's transcriptional activity by increasing C-terminal flexibility, enabling better DNA binding with p52:p52 complexes, and linking structural changes to cancer-related mutations.

A 10-valent composite mRNA vaccine against both influenza and COVID-19

This paper introduces FLUCOV-10, a 10-valent mRNA vaccine targeting influenza and SARS-CoV-2, showing robust immune responses and complete protection in mice against multiple strains.

Ultraviolet attenuates centromere-mediated meiotic genome stability and alters gametophytic ploidy consistency in flowering plants

This study shows UV radiation reduces crossover rates and disrupts meiotic spindle organization in Arabidopsis, leading to unreduced gametes and altered genome stability.

Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer.

This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.

Genetic basis of expression and splicing underlying spike architecture in wheat (Triticum aestivum L.)

This study identifies eQTLs and sQTLs associated with spike architecture in wheat, revealing genetic factors that regulate gene expression and splicing related to yield traits.

Real-Time Quantification of Cell Mechanics and Functions by Double Resonator Piezoelectric Cytometry -Theory and Study of Cellular Adhesion of HUVECs

This paper introduces DRPC to measure cell-generated forces and viscoelastic moduli in real time, showing ligand and cell density affect mechanical properties of HUVECs.

A pair of NLRs coordinately modulates NRC3-mediated ETI responses to facilitate age-dependent immunity

The paper identifies paired NLRs in Solanaceae species and shows their coordinated role in modulating NRC3-mediated ETI to enhance age-dependent immunity.

Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation

This study determines the structure of NF-κB p52 homodimer-DNA complexes and shows how DNA conformation and binding kinetics influence transcriptional activation.

Efficient transformation and genome editing of watermelon assisted by genes that encode developmental regulators

This study improves watermelon transformation efficiency using AtGRF5 and Agrobacterium GV3101, achieving 25% efficiency and enabling CRISPR/Cas9-based knockout mutants.

m6A modifications regulate intestinal immunity and rotavirus infection

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

Genome-wide identification and characterization of DNA/RNA differences associated with Fusarium graminearum infection in wheat

This study identifies 187 DNA/RNA differences in 36 wheat genes associated with Fusarium head blight, showing their role in regulating FHB response through structural changes and miRNA interactions.

METTL9 regulates N1-histidine methylation of zinc transporters to promote tumor growth

This study identifies METTL9 as a tumor-promoting methyltransferase that methylates zinc transporters, disrupting zinc homeostasis and promoting cancer growth.

Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers predicting HBsAg loss

This study identifies immune markers, including HLA-DR and CTLA-4 expression on CD4 T cells, that predict HBsAg loss in chronic hepatitis B patients.

A high affinity human monoclonal antibody against Pfs230 binds multiple parasite stages and blocks oocyst formation in mosquitoes

The paper identifies a high-affinity human monoclonal antibody against Pfs230 that blocks oocyst formation in mosquitoes by targeting gamete surfaces.

TSC-Insensitive Rheb Mutations Induce Oncogenic Transformation Through a Combination of Hyperactive mTORC1 Signalling and Metabolic Reprogramming

This study identifies two Rheb mutants that drive oncogenic transformation via hyperactive mTORC1 signaling and distinct metabolic reprogramming pathways.

Integrative Molecular Characterization of Sarcomatoid and Rhabdoid Renal Cell Carcinoma Reveals Determinants of Poor Prognosis and Response to Immune Checkpoint Inhibitors

This study characterizes the molecular features and immune profile of sarcomatoid and rhabdoid renal cell carcinoma, showing their responsiveness to immune checkpoint inhibitors and identifying key genetic and transcriptional determinants.

Rotten-skin disease significantly changed giant spiny frog(Paa spinosa) gut microbiota

This study compares gut microbiota composition between healthy and rotten-skin diseased giant spiny frogs using 16S rRNA sequencing and identifies significant microbial abundance differences.

In vitro pancreatic islet cluster expansion facilitated by hormones and chemicals

This study describes a method to expand pancreatic islet clusters in vitro using hormones and chemicals, resulting in functional islet-like structures with cell type markers.

Geomagnetic field intensity as a cue for the regulation of insect migration

The paper tests how changes in geomagnetic field intensity affect migration-related traits in the brown planthopper, finding responses in morphology, behavior, and physiology.

Geomagnetic field absence reduces adult body weight of a migratory insect by disrupting feeding behavior and appetite regulation

This study shows that absence of geomagnetic field reduces feeding in brown planthopper nymphs, leading to lower body weight and altered glucose levels and appetite-related gene expression.

The Abnormal Oswald Ripening of Protein Nanofiber in Myofibrillar Protein Solution

The paper studies abnormal Ostwald ripening in myofibrillar protein nanofibers from giant squid, showing temperature-dependent conformational changes and redistribution of protein molecules.

Humans are colonized by many uncharacterized and highly divergent microbes

The paper identifies hundreds of new bacteria and viruses in the human microbiome using blood-based shotgun sequencing and validates their existence through independent experiments and PCR.