Author

J. Bruning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Organism:E. coli· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. A. Hennrich· 1 shared A. Harvgreaves· 1 shared A. Heimsoeth· 1 shared A. Placzek· 1 shared A. Schmitt· 1 shared A. Syeda· 1 shared A. Wollman· 1 shared C. G. Proud· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. A. Hennrich

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Functional synapses between small cell lung cancer and glutamatergic neurons

A. Schmitt, V. Sakthivelu, K. Ndoci, G. A. Wani, M. Touet, I. Pintelon, I. Kisis, O. Ibruli, J. Weber, R. Maresch, C. M. Bebber, J. Goergens, M. Jevtic, F. Odenthal, A. Placzek, , F. Beleggia

This study identifies glutamatergic synaptic interactions between SCLC cells and neurons, showing that these interactions support tumor growth and can be targeted therapeutically.

bioRxiv · Jan 19, 2023Cancer Biology

TSC-Insensitive Rheb Mutations Induce Oncogenic Transformation Through a Combination of Hyperactive mTORC1 Signalling and Metabolic Reprogramming

C. G. Proud, S. P. De Poi, J. Xie, S. J. Humphrey, L. K. Hein, J. Bruning, W. Pan, T. J. Sargeant

This study identifies two Rheb mutants that drive oncogenic transformation via hyperactive mTORC1 signaling and distinct metabolic reprogramming pathways.

bioRxiv · Sep 5, 2020Cell Biology

Single-molecule live cell imaging of Rep reveals the dynamic interplay between an accessory replicative helicase and the replisome

A. Syeda, A. Wollman, A. Harvgreaves, J. Bruning, P. McGlynn, M. Leake

The paper uses single-molecule live cell imaging to study the dynamic interactions of the bacterial helicase Rep with the replisome and PriC, revealing two distinct mechanisms for overcoming nucleoprotein barriers during DNA replication.

bioRxiv · Sep 29, 2018Biophysics