MicrobiologybioRxiv
Systematic analysis of IL-1 cytokine signaling suppression by high-risk HPV oncoproteins
P. Castagnino, H. W. Kim, L. K. M. Lam…·E. A. White
This study shows that HPV16 E6 and E7 oncoproteins suppress IL-1β signaling in both early and late stages of HPV-induced carcinogenesis by upregulating suppressors like SIGIRR.
DOI 10.1128/jvi.01326-22