D. Basu

Heterogeneous and Novel Transcript Expression in Single Cells of Patient-Derived ccRCC Organoids

This study uses single-cell long-read sequencing to analyze transcriptomes of ccRCC organoids, identifying novel transcripts and highlighting cell-specific alternative splicing events.

Systematic analysis of IL-1 cytokine signaling suppression by high-risk HPV oncoproteins

This study shows that HPV16 E6 and E7 oncoproteins suppress IL-1β signaling in both early and late stages of HPV-induced carcinogenesis by upregulating suppressors like SIGIRR.

Cancer type-specific prioritization strategy for targetable dependencies developed from the DepMap profile of head and neck cancer

This paper identifies cancer type-specific gene dependencies in head and neck cancer using DepMap CRISPR screens, highlighting novel therapeutic targets and synthetic lethalities.

Human papilloma virus E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis

This study shows that HPV E6 reduces mitochondrial antioxidant capacity and therapy resistance in oropharyngeal cancer by suppressing the PGC-1α/ERRα pathway.

YAP1 Activation by Human Papillomavirus E7 Promotes Basal Cell Identity in Squamous Epithelia

This study shows that HPV E7 activates YAP1, promoting basal cell identity and contributing to HPV persistence and carcinogenesis.

The Mechanosensitive Ion Channel MSL10 Modulates Susceptibility to Pseudomonas syringae in Arabidopsis thaliana

This study shows that the mechanosensitive ion channel MSL10 modulates Arabidopsis susceptibility to Pseudomonas syringae by affecting immune responses and stomatal closure.

T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma

This study shows T2R bitter taste receptors in HNSCC promote apoptosis and are linked to better patient survival.

Interactions between the N- and C- termini of mechanosensitive ion channel AtMSL10 are consistent with a three-step mechanism for activation

The paper investigates how mutations in the N- and C-termini of the plant mechanosensitive ion channel AtMSL10 trigger cell death and proposes a three-step activation mechanism involving conformational changes and dephosphorylation.

The Mechanosensitive Ion Channel MSL10 Potentiates Responses to Cell Swelling in Arabidopsis Seedlings

This study identifies MSL10 as a phospho-regulated mechanosensitive ion channel that mediates cell swelling responses in Arabidopsis seedlings, including calcium transients, ROS accumulation, and programmed cell death.

Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models

This study identifies predictors of HPV-related head and neck squamous cell carcinoma progression and survival using patient-derived models and finds associations between mutational burden and E2F target dysregulation with clinical outcomes.