Author

L. Koob

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

B. van den Broek· 2 shared F. M. Feringa· 2 shared L. Krenning· 2 shared R. H. Medema· 2 shared A. Friskes· 1 shared A. G. Manjon· 1 shared E. S. Koeleman· 1 shared J. van den Berg· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

B. van den Broek

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2 papers

Recent·Most cited

MND1 enables repair of two-ended DNA double-strand breaks

L. Koob, A. Friskes, L. van Bergen, F. M. Feringa, B. van den Broek, E. S. Koeleman, M. Schubert, V. A. Blomen, T. R. Brummelkamp, L. Krenning, R. H. Medema

This study shows MND1 facilitates repair of two-ended DNA double-strand breaks in somatic cells through homologous recombination, but not one-ended breaks, and its absence increases IR-induced toxicity.

bioRxiv · Aug 24, 2022 · PreprintCell Biology

DNA end-resection in highly accessible chromatin produces a toxic break

J. van den Berg, S. E. P. Joosten, Y. Kim, A. G. Manjon, L. Krenning, L. Koob, F. M. Feringa, R. Klompmaker, B. van den Broek, K. Jalink, W. Zwart, R. H. Medema

The authors withdrew their manuscript due to inconsistencies in data and questionable experimental results regarding DNA end-resection and chromatin accessibility.

bioRxiv · Aug 30, 2021 · PreprintCell Biology