Author

L. Krenning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

R. H. Medema· 3 shared B. van den Broek· 2 shared F. M. Feringa· 2 shared L. Koob· 2 shared M. E. Tanenbaum· 2 shared A. Akhmanova· 1 shared A. E. Prota· 1 shared A. Friskes· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

R. H. Medema

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

MND1 enables repair of two-ended DNA double-strand breaks

L. Koob, A. Friskes, L. van Bergen, F. M. Feringa, B. van den Broek, E. S. Koeleman, M. Schubert, V. A. Blomen, T. R. Brummelkamp, L. Krenning, R. H. Medema

This study shows MND1 facilitates repair of two-ended DNA double-strand breaks in somatic cells through homologous recombination, but not one-ended breaks, and its absence increases IR-induced toxicity.

bioRxiv · Aug 24, 2022 · PreprintCell Biology

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity

Z. Pogacar, J. L. Johnson, L. Krenning, G. De Conti, C. Lieftink, A. Velds, L. Wardak, F. Jochems, K. Groot, A. Schepers, L. Wang, J.-Y. Song, M. van de Ven, O. van Tellingen, R. H. Medema, , R. Leite de Oliveira

The paper identifies that combining indisulam with palbociclib enhances senescence in cancer cells by inhibiting CDK2 kinase activity.

bioRxiv · Oct 18, 2021Cancer Biology

DNA end-resection in highly accessible chromatin produces a toxic break

J. van den Berg, S. E. P. Joosten, Y. Kim, A. G. Manjon, L. Krenning, L. Koob, F. M. Feringa, R. Klompmaker, B. van den Broek, K. Jalink, W. Zwart, R. H. Medema

The authors withdrew their manuscript due to inconsistencies in data and questionable experimental results regarding DNA end-resection and chromatin accessibility.

bioRxiv · Aug 30, 2021 · PreprintCell Biology

Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during mitotic exit

L. Krenning, S. Sonneveld, M. E. Tanenbaum

The paper identifies two sequential waves of mRNA decay during mitosis-to-G1 transition and links CNOT1 to this process.

bioRxiv · Apr 17, 2021Cell Biology

Pharmaceutical-grade Rigosertib is a Microtubule-destabilizing Agent

M. Jost, Y. Chen, L. A. Gilbert, M. A. Horlbeck, L. Krenning, G. Menchon, A. Rai, M. Y. Cho, J. J. Stern, A. E. Prota, M. Kampmann, A. Akhmanova, M. O. Steinmetz, M. E. Tanenbaum, J. S. Weissman

This paper shows pharmaceutical-grade rigosertib, with high purity, causes microtubule destabilization in cells, confirming its mechanism of action against cancer cells.

bioRxiv · Jan 28, 2020Cancer Biology