Suramin potently inhibits binding of the mammalian high mobility group protein AT-hook 2 to DNA
L. Su, N. Bryan, S. Battista, J. Freitas, A. Garabedian, F. DAlessio, M. Romano, F. Falanga, A. Fusco, L. Kos, J. Chambers, F. Fernandez-Lima, P. P. Chapagain, S. Vasile, L. Smith, F. Leng
This study identifies suramin as a potent inhibitor of HMGA2-DNA binding, showing it disrupts HMGA2 function and induces differentiation of brain tumor stem cells.
bioRxiv · Nov 12, 2019 · PreprintBiochemistry